Detalhes

Chemoselective and Bioorthogonal Ligation Reactions : Concepts and Applications

autor:

W. Russ Algar; Philip Dawson; Igor L. Medintz

editor:

Wiley-VCH

edição:

ano de publicação:

2014

idioma:

Inglês

ISBN:

9783527683444

nº de páginas:

430

formato:

(leitura online e APP)

ver edição impressa imprimir

Acesso Perpétuo 223,99 €

Descrição
Índice de conteúdos
Temática
Condições de utilização

This timely, one-stop reference is the first on an emerging and interdisciplinary topic. Covering both established and recently developed ligation chemistries, the book is divided into two didactic parts: a section that focuses on the details of bioorthogonal and chemoselective ligation reactions at the level of fundamental organic chemistry, and a section that focuses on applications, particularly in the areas of chemical biology, biomaterials, and bioanalysis, highlighting the capabilities and benefits of the ligation reactions. With chapters authored by outstanding scientists who range from trailblazers in the field to young and emerging leaders, this book on a highly interdisciplinary topic will be of great interest for biochemists, biologists, materials scientists, pharmaceutical chemists, organic chemists, and many others.

PREFACE
PART 1: CONCEPTS
A Brief Introduction to Traditional Bioconjugate Chemistry
[3+2] Dipolar Cycloadditions in Bioconjugation
Diels-Alder and Inverse Diels-Alder Reactions
The Staudinger Ligation
Thiol-Ene Chemistry
Ligand-Directed Tosyl and Acyl Imidazole Chemistry
Bioorthogonal Labeling of Cellular Proteins by Enzymatic and Related Mechanisms
Metal-Mediated Bioconjugation
PART 2: APPLICATIONS
Protein and Antibody Labeling
Activity-Based Protein Profiling
Nucleic Acid Labelling, Ligation, and Modification
Chemoselective Reactions for Glycan Labeling
Chemoselective Attachment of Lipids to Proteins
In Vivo Applications of Bioorthogonal Chemistries
Immobilization of Biomolecular Probes for Arrays and Assay: Critical Aspects of Biointerfaces
Chemical Ligations in the Design of Hydrogel Materials
Nanoparticle Bioconjugates: Materials that Benefit from Chemoselective and Bioorthogonal Ligation Chemistries
Application of Engineered Viral Nanoparticles in Materials and Medicine

Informação indisponível

Pessoal

Tipo de licença	Permissão de impressão	Permissão de cópia
Acesso Perpétuo	não permitido

Leitura online: um utilizador por sessão (sem simultaneidade)
Leitura offline (com a APP): máximo de 2 dispositivos em simultâneo

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